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Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. TDP-43 (TAR DNA-binding protein 43) and FUS (fused in sarcoma) are aggregation-prone RNA-binding proteins that in ALS can mislocalize to the cytoplasm of affected motor neuron cells, often forming cytoplasmic aggregate...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996276/ https://ncbi.nlm.nih.gov/pubmed/31767634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00256-19 |
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