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Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity

Limb-specific Shh expression is regulated by the (∼1 Mb distant) ZRS enhancer. In the mouse, limb bud-restricted spatiotemporal Shh expression occurs from ∼E10 to E11.5 at the distal posterior margin and is essential for correct autopod formation. Here, we have analysed the higher-order chromatin co...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Development
Päätekijät: Williamson, Iain, Lettice, Laura A., Hill, Robert E., Bickmore, Wendy A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004883/
https://ncbi.nlm.nih.gov/pubmed/27402708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139188
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