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Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC

Folate deficiency in fetal life is strongly associated with structural malformations and linked to intrauterine growth restriction. In addition, limited availability of methyl donors, such as folate, during pregnancy may result in abnormal gene methylation patterns and contribute to developmental pr...

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Pubblicato in:Sci Rep
Autori principali: Rosario, Fredrick J., Powell, Theresa L., Jansson, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999868/
https://ncbi.nlm.nih.gov/pubmed/27562465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31705
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