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mTOR folate sensing links folate availability to trophoblast cell function

KEY POINTS: Folate deficiency during pregnancy is associated with restricted fetal growth, although the underlying mechanisms are poorly understood. Here we show that mechanistic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells. Folate sensing by mTOR...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Rosario, Fredrick J., Powell, Theresa L., Jansson, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491891/
https://ncbi.nlm.nih.gov/pubmed/28374905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272424
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