mTOR folate sensing links folate availability to trophoblast cell function

Eitemau Tebyg

• Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
  gan: Rosario, Fredrick J., et al.
  Cyhoeddwyd: (2016)
• Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function
  gan: Silva, Elena, et al.
  Cyhoeddwyd: (2017)
• Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
  gan: Rosario, Fredrick J., et al.
  Cyhoeddwyd: (2017)
• Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction
  gan: Ellen C. Francis, et al.
  Cyhoeddwyd: (2025-11-01)
• Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth
  gan: Rosario, Fredrick J., et al.
  Cyhoeddwyd: (2015)