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Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity

Anticonvulsants can increase the risk of developing neurotoxicity in infants; however, the underlying mechanism has not been elucidated to date. Thyroxine [3,5,3′,5′-l-tetraiodothyronine (T(4))] plays crucial roles in the development of the central nervous system. In this study, we hypothesized that...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Hirashima, Rika, Michimae, Hirofumi, Takemoto, Hiroaki, Sasaki, Aya, Kobayashi, Yoshinori, Itoh, Tomoo, Tukey, Robert H., Fujiwara, Ryoichi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998668/
https://ncbi.nlm.nih.gov/pubmed/27413119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.104174
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