Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

Large genomic sequencing analysis as part of precision medicine efforts revealed numerous activating mutations in receptor tyrosine kinases, including KIT. Unfortunately, a single approach is not effective for inhibiting cancer cells or treating cancers driven by all known oncogenic KIT mutants. Her...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shi, Xiarong, Sousa, Leiliane P., Mandel-Bausch, Elizabeth M., Tome, Francisco, Reshetnyak, Andrey V., Hadari, Yaron, Schlessinger, Joseph, Lax, Irit
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995958/
https://ncbi.nlm.nih.gov/pubmed/27482095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610179113
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