Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

Large genomic sequencing analysis as part of precision medicine efforts revealed numerous activating mutations in receptor tyrosine kinases, including KIT. Unfortunately, a single approach is not effective for inhibiting cancer cells or treating cancers driven by all known oncogenic KIT mutants. Her...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shi, Xiarong, Sousa, Leiliane P., Mandel-Bausch, Elizabeth M., Tome, Francisco, Reshetnyak, Andrey V., Hadari, Yaron, Schlessinger, Joseph, Lax, Irit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995958/
https://ncbi.nlm.nih.gov/pubmed/27482095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610179113
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