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Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT protomers form close contacts throughout the entire structure of ligand-bound receptor dimers, and that the dimeric rece...

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Main Authors: Opatowsky, Yarden, Lax, Irit, Tomé, Francisco, Bleichert, Franziska, Unger, Vinzenz M., Schlessinger, Joseph
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918759/
https://ncbi.nlm.nih.gov/pubmed/24449920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323254111
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