A carregar...

The Strength And Cooperativity of Contacts in KIT Extracellular Domain Determine Normal Ligand Dependent Stimulation or Oncogenic Activation in Cancer

The receptor tyrosine kinase KIT plays an important role in development of germ cells, hematopoietic cells and interstitial pacemaker cells. Oncogenic KIT mutations play an important `driver' role in gastrointestinal stromal tumors, acute myeloid leukemias and melanoma among other cancers. Here...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Reshetnyak, Andrey V., Opatowsky, Yarden, Boggon, Titus J., Folta-Stogniew, Ewa, Tome, Francisco, Lax, Irit, Schlessinger, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764128/
https://ncbi.nlm.nih.gov/pubmed/25544564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.021
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!