The Strength And Cooperativity of Contacts in KIT Extracellular Domain Determine Normal Ligand Dependent Stimulation or Oncogenic Activation in Cancer

The receptor tyrosine kinase KIT plays an important role in development of germ cells, hematopoietic cells and interstitial pacemaker cells. Oncogenic KIT mutations play an important `driver' role in gastrointestinal stromal tumors, acute myeloid leukemias and melanoma among other cancers. Here...

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Udgivet i:Mol Cell
Main Authors: Reshetnyak, Andrey V., Opatowsky, Yarden, Boggon, Titus J., Folta-Stogniew, Ewa, Tome, Francisco, Lax, Irit, Schlessinger, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764128/
https://ncbi.nlm.nih.gov/pubmed/25544564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.021
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