Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

Somatic oncogenic mutations in the receptor tyrosine kinase KIT function as major drivers of gastrointestinal stromal tumors and a subset of acute myeloid leukemia, melanoma, and other cancers. Although treatment of these cancers with tyrosine kinase inhibitors shows dramatic responses and durable d...

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Autors principals: Reshetnyak, Andrey V., Nelson, Bryce, Shi, Xiarong, Boggon, Titus J., Pavlenco, Alevtina, Mandel-Bausch, Elizabeth M., Tome, Francisco, Suzuki, Yoshihisa, Sidhu, Sachdev S., Lax, Irit, Schlessinger, Joseph
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816449/
https://ncbi.nlm.nih.gov/pubmed/24127596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317118110
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