Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand–receptor interactions

Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic lymphoma kinase (ALK) is one of very few RTKs that remain without a firmly established protein ligand. Here we present...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Reshetnyak, Andrey V., Murray, Phillip B., Shi, Xiarong, Mo, Elizabeth S., Mohanty, Jyotidarsini, Tome, Francisco, Bai, Hanwen, Gunel, Murat, Lax, Irit, Schlessinger, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702955/
https://ncbi.nlm.nih.gov/pubmed/26630010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520099112
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