Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest Induced Brain Injury

BACKGROUND: Neurocognitive dysfunction and injury remain problematic following cardiac procedures requiring hypothermic circulatory arrest (HCA). Due to poor blood-brain-barrier (BBB) penetrance and toxicities associated with systemic drug therapies, clinical success has been elusive. Accordingly, w...

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Detalhes bibliográficos
Publicado no:Ann Thorac Surg
Main Authors: Grimm, Joshua C., Magruder, J. Trent, Wilson, Mary A., Blue, Mary E., Crawford, Todd C., Troncoso, Juan C., Zhang, Fan, Kannan, Sujatha, Sciortino, Christopher M., Johnston, Michael V., Kannan, Rangaramanujam M., Baumgartner, William A
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995124/
https://ncbi.nlm.nih.gov/pubmed/27154161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2016.02.077
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