Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest Induced Brain Injury

BACKGROUND: Neurocognitive dysfunction and injury remain problematic following cardiac procedures requiring hypothermic circulatory arrest (HCA). Due to poor blood-brain-barrier (BBB) penetrance and toxicities associated with systemic drug therapies, clinical success has been elusive. Accordingly, w...

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Pubblicato in:Ann Thorac Surg
Autori principali: Grimm, Joshua C., Magruder, J. Trent, Wilson, Mary A., Blue, Mary E., Crawford, Todd C., Troncoso, Juan C., Zhang, Fan, Kannan, Sujatha, Sciortino, Christopher M., Johnston, Michael V., Kannan, Rangaramanujam M., Baumgartner, William A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995124/
https://ncbi.nlm.nih.gov/pubmed/27154161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2016.02.077
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