Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest Induced Brain Injury

BACKGROUND: Neurocognitive dysfunction and injury remain problematic following cardiac procedures requiring hypothermic circulatory arrest (HCA). Due to poor blood-brain-barrier (BBB) penetrance and toxicities associated with systemic drug therapies, clinical success has been elusive. Accordingly, w...

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Publicat a:Ann Thorac Surg
Autors principals: Grimm, Joshua C., Magruder, J. Trent, Wilson, Mary A., Blue, Mary E., Crawford, Todd C., Troncoso, Juan C., Zhang, Fan, Kannan, Sujatha, Sciortino, Christopher M., Johnston, Michael V., Kannan, Rangaramanujam M., Baumgartner, William A
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995124/
https://ncbi.nlm.nih.gov/pubmed/27154161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2016.02.077
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