Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest

BACKGROUND: Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury. We have previously shown that hypothermic circulatory arrest causes both neuronal apoptosis and necrosis in a canine model. Inhibition of neuronal nitric oxide synthase reduced neuronal apoptos...

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Main Authors: Tseng, Elaine E., Brock, Malcolm V., Lange, Mary S., Troncoso, Juan C., Blue, Mary E., Lowenstein, Charles J., Johnston, Michael V., Baumgartner, William A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076934/
https://ncbi.nlm.nih.gov/pubmed/20103318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2009.10.059
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