Alpha II-spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest

BACKGROUND: The development of specific biomarkers to aid in diagnosis and prognosis of neuronal injury is of paramount importance in cardiac surgery. Alpha II-spectrin is a structural protein abundant in neurons of the central nervous system and cleaved into signature fragments by proteases involve...

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Main Authors: Weiss, Eric S., Wang, Kevin K.W., Allen, Jeremiah G., Blue, Mary E., Nwakanma, Lois U., Liu, Ming Cheng, Lange, Mary S., Berrong, Jennifer, Wilson, Mary Ann, Gott, Vincent L., Troncoso, Juan C., Hayes, Ronald L., Johnston, Michael V., Baumgartner, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412404/
https://ncbi.nlm.nih.gov/pubmed/19632410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2009.04.016
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