Reversal of a Single Base‐Pair Step Controls Guanine Photo‐Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo‐oxidation by Λ‐[Ru(TAP)(2)(dppz)](2+) have been compared in 5′‐{CCGGATCCGG}(2) and 5′‐{CCGGTACCGG}(2) using pico/nanosecond transient visible and time‐resolved IR (TRIR) spectroscopy. Th...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY‐VCH Verlag 2015
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985698/
https://ncbi.nlm.nih.gov/pubmed/26096623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502608
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