Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects

X‐ray crystal structures of three Λ‐[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10‐phenanthroline (phen), 2,2′‐bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5′‐CG‐3′ step. The compounds bind through canted intercalation, with the binding angle dete...

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Bibliographic Details
Published in:Chemistry
Main Authors: Hall, James P., Gurung, Sarah P., Henle, Jessica, Poidl, Patrick, Andersson, Johanna, Lincoln, Per, Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412927/
https://ncbi.nlm.nih.gov/pubmed/28105682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201605508
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