Reversal of a Single Base‐Pair Step Controls Guanine Photo‐Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo‐oxidation by Λ‐[Ru(TAP)(2)(dppz)](2+) have been compared in 5′‐{CCGGATCCGG}(2) and 5′‐{CCGGTACCGG}(2) using pico/nanosecond transient visible and time‐resolved IR (TRIR) spectroscopy. Th...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY‐VCH Verlag 2015
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985698/
https://ncbi.nlm.nih.gov/pubmed/26096623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502608
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