Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

PURPOSE: Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleti...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Goff, Stephanie L., Dudley, Mark E., Citrin, Deborah E., Somerville, Robert P., Wunderlich, John R., Danforth, David N., Zlott, Daniel A., Yang, James C., Sherry, Richard M., Kammula, Udai S., Klebanoff, Christopher A., Hughes, Marybeth S., Restifo, Nicholas P., Langhan, Michelle M., Shelton, Thomas E., Lu, Lily, Kwong, Mei Li M., Ilyas, Sadia, Klemen, Nicholas D., Payabyab, Eden C., Morton, Kathleen E., Toomey, Mary Ann, Steinberg, Seth M., White, Donald E., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2016
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981979/
https://ncbi.nlm.nih.gov/pubmed/27217459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.66.7220
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