CD8+ enriched “young” tumor infiltrating lymphocytes can mediate regression of metastatic melanoma

PURPOSE: Tumor infiltrating lymphocytes (TIL) and interleukin (IL)-2 administered following lymphodepletion can cause the durable complete regression of bulky metastatic melanoma in patients refractory to approved treatments. However, the generation of a unique tumor-reactive TIL culture for each pa...

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Autori principali: Dudley, Mark E., Gross, Colin A., Langhan, Michelle M., Garcia, Marcos R., Sherry, Richard M., Yang, James C., Phan, Giao Q., Kammula, Udai S., Hughes, Marybeth S., Citrin, Deborah E., Restifo, Nicholas P., Wunderlich, John, Prieto, Peter A., Hong, Jenny J., Langan, Russell C., Zlott, Daniel A., Morton, Kathleen E., White, Donald E., Laurencot, Carolyn, Rosenberg, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978753/
https://ncbi.nlm.nih.gov/pubmed/20668005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1297
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