Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors

Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC complex, composed of Rhino, Deadlock and Cutoff (Cuff) binds chromatin of dual-strand piRNA clusters, special genomic regions, which...

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Publicat a:Mol Cell
Autors principals: Chen, Yung-Chia Ariel, Stuwe, Evelyn, Luo, Yicheng, Ninova, Maria, Le Thomas, Adrien, Rozhavskaya, Ekaterina, Li, Sisi, Vempati, Sivani, Laver, John D., Patel, Dinshaw J., Smibert, Craig A., Lipshitz, Howard D., Toth, Katalin Fejes, Aravin, Alexei A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980073/
https://ncbi.nlm.nih.gov/pubmed/27292797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.010
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