APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cy...

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Publicat a:J Neurosci
Autors principals: Manocha, Gunjan D., Floden, Angela M., Rausch, Keiko, Kulas, Joshua A., McGregor, Brett A., Rojanathammanee, Lalida, Puig, Kelley R., Puig, Kendra L., Karki, Sanjib, Nichols, Michael R., Darland, Diane C., Porter, James E., Combs, Colin K.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978805/
https://ncbi.nlm.nih.gov/pubmed/27511018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4654-15.2016
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