APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cy...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Manocha, Gunjan D., Floden, Angela M., Rausch, Keiko, Kulas, Joshua A., McGregor, Brett A., Rojanathammanee, Lalida, Puig, Kelley R., Puig, Kendra L., Karki, Sanjib, Nichols, Michael R., Darland, Diane C., Porter, James E., Combs, Colin K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978805/
https://ncbi.nlm.nih.gov/pubmed/27511018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4654-15.2016
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