APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Manocha, Gunjan D., Floden, Angela M., Rausch, Keiko, Kulas, Joshua A., McGregor, Brett A., Rojanathammanee, Lalida, Puig, Kelley R., Puig, Kendra L., Karki, Sanjib, Nichols, Michael R., Darland, Diane C., Porter, James E., Combs, Colin K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2016
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978805/
https://ncbi.nlm.nih.gov/pubmed/27511018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4654-15.2016
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