APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cy...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Manocha, Gunjan D., Floden, Angela M., Rausch, Keiko, Kulas, Joshua A., McGregor, Brett A., Rojanathammanee, Lalida, Puig, Kelley R., Puig, Kendra L., Karki, Sanjib, Nichols, Michael R., Darland, Diane C., Porter, James E., Combs, Colin K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978805/
https://ncbi.nlm.nih.gov/pubmed/27511018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4654-15.2016
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