αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy

AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI progression to CKD has not been studied. We altered systemic αKlotho levels by genetic manipulation, phosphate loa...

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Publicat a:J Am Soc Nephrol
Autors principals: Shi, Mingjun, Flores, Brianna, Gillings, Nancy, Bian, Ao, Cho, Han Jun, Yan, Shirley, Liu, Yang, Levine, Beth, Moe, Orson W., Hu, Ming Chang
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2016
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978045/
https://ncbi.nlm.nih.gov/pubmed/26701976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060613
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