Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho

Klotho- and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho’s known renoprotective action in AKI. AKI was induced by ischemia-reperfusion injury in mice with different levels of autophagy activity by...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Renal Physiol
Asıl Yazarlar: Li, Peng, Shi, Mingjun, Maique, Jenny, Shaffer, Joy, Yan, Shirley, Moe, Orson W., Hu, Ming Chang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099499/
https://ncbi.nlm.nih.gov/pubmed/31984794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00504.2019
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