αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy

AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI progression to CKD has not been studied. We altered systemic αKlotho levels by genetic manipulation, phosphate loa...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Shi, Mingjun, Flores, Brianna, Gillings, Nancy, Bian, Ao, Cho, Han Jun, Yan, Shirley, Liu, Yang, Levine, Beth, Moe, Orson W., Hu, Ming Chang
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2016
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978045/
https://ncbi.nlm.nih.gov/pubmed/26701976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060613
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