Structural mechanism of ligand activation in human calcium-sensing receptor

Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that maintains extracellular Ca(2+) homeostasis through the regulation of parathyroid hormone secretion. It functions as a disulfide-tethered homodimer composed of three main domains, the Venus Flytrap module, cysteine-rich...

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Pubblicato in:eLife
Autori principali: Geng, Yong, Mosyak, Lidia, Kurinov, Igor, Zuo, Hao, Sturchler, Emmanuel, Cheng, Tat Cheung, Subramanyam, Prakash, Brown, Alice P, Brennan, Sarah C, Mun, Hee-chang, Bush, Martin, Chen, Yan, Nguyen, Trang X, Cao, Baohua, Chang, Donald D, Quick, Matthias, Conigrave, Arthur D, Colecraft, Henry M, McDonald, Patricia, Fan, Qing R
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Biophysics and Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977154/
https://ncbi.nlm.nih.gov/pubmed/27434672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13662
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