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LQT1 mutations in KCNQ1 C-terminus assembly domain suppress I(Ks) using different mechanisms
AIMS: Long QT syndrome 1 (LQT1) mutations in KCNQ1 that decrease cardiac I(Ks) (slowly activating delayed rectifier K(+) current) underlie ventricular arrhythmias and sudden death. LQT1 mutations may suppress I(Ks) by preventing KCNQ1 assembly, disrupting surface trafficking, or inhibiting gating. W...
Gorde:
| Argitaratua izan da: | Cardiovasc Res |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4296111/ https://ncbi.nlm.nih.gov/pubmed/25344363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu231 |
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