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Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of I(Ks) channels
The slow delayed rectifier K(+) current (I(Ks)) is a major determinant of action potential repolarization in the heart. I(Ks) channels are formed by coassembly of pore-forming KCNQ1 α-subunits and ancillary KCNE1 β-subunits. Two gain of function mutations in KCNQ1 subunits (S140G and V141M) have bee...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652179/ https://ncbi.nlm.nih.gov/pubmed/18599533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.157511 |
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