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Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations
KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate I(Ks), the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential. Two KCNQ1 gain-of-function mutations that cause a genetic form of atrial fibrillatio...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5382920/ https://ncbi.nlm.nih.gov/pubmed/28383569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45911 |
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