Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1

The I(Ks) potassium channel, critical to control of heart electrical activity, requires assembly of α (KCNQ1) and β (KCNE1) subunits. Inherited mutations in either I(Ks) channel subunit are associated with cardiac arrhythmia syndromes. Two mutations (S140G and V141M) that cause familial atrial fibri...

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Bibliografiska uppgifter
Huvudupphovsmän: Chan, Priscilla J., Osteen, Jeremiah D., Xiong, Dazhi, Bohnen, Michael S., Doshi, Darshan, Sampson, Kevin J., Marx, Steven O., Karlin, Arthur, Kass, Robert S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269792/
https://ncbi.nlm.nih.gov/pubmed/22250012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110672
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