Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The intracellular domains of many ion channels are important for fine-tuning their gating kinetics. In Kv11.1 channels, the slow kinetics of channel deactivation, which are critical for their function in the heart, are largely regulated by the N-terminal N-Cap and Per-Arnt-Sim (PAS) domains, as well...

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Main Authors: Ng, Chai Ann, Phan, Kevin, Hill, Adam P., Vandenberg, Jamie I., Perry, Matthew D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Molecular Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162183/
https://ncbi.nlm.nih.gov/pubmed/25074935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558379
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