Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

di Perry, Matthew D., Ng, Chai Ann, Vandenberg, Jamie I.
Pubblicazione 2013

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

di Perry, Matthew D., Wong, Sophia, Ng, Chai Ann, Vandenberg, Jamie I.
Pubblicazione 2013

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

di Tan, Peter S., Perry, Matthew D., Ng, Chai Ann, Vandenberg, Jamie I., Hill, Adam P.
Pubblicazione 2012

Role of the Cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) Domain in Trafficking and Stabilization of Kv11.1 Channels

di Ke, Ying, Hunter, Mark J., Ng, Chai Ann, Perry, Matthew D., Vandenberg, Jamie I.
Pubblicazione 2014

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

di Ng, Chai Ann, Phan, Kevin, Hill, Adam P., Vandenberg, Jamie I., Perry, Matthew D.
Pubblicazione 2014

C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels

di Ng, Chai Ann, Ke, Ying, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Vandenberg, Jamie I.
Pubblicazione 2013

The S4–S5 Linker Acts as a Signal Integrator for hERG K(+) Channel Activation and Deactivation Gating

di Ng, Chai Ann, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Kuchel, Philip W., Vandenberg, Jamie I.
Pubblicazione 2012

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

di Ng, Chai-Ann, Gravel, Andrée E., Perry, Matthew D., Arnold, Alexandre A., Marcotte, Isabelle, Vandenberg, Jamie I.
Pubblicato in J Biol Chem (2016)

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

di Phan, Kevin, Ng, Chai Ann, David, Erikka, Shishmarev, Dmitry, Kuchel, Philip W., Vandenberg, Jamie I., Perry, Matthew D.
Pubblicato in J Biol Chem (2017)

Getting to the heart of hERG K(+) channel gating

di Perry, Matthew D, Ng, Chai-Ann, Mann, Stefan A, Sadrieh, Arash, Imtiaz, Mohammad, Hill, Adam P, Vandenberg, Jamie I
Pubblicato in J Physiol (2015)

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

di Ng, Chai-Ann, Farr, Jessica, Young, Paul, Windley, Monique J, Perry, Matthew D, Hill, Adam P, Vandenberg, Jamie I
Pubblicato in Biol Methods Protoc (2021)

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

di Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela, Vandenberg, Jamie I.
Pubblicazione 2011

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

di Cox, Charles D., Bae, Chilman, Ziegler, Lynn, Hartley, Silas, Nikolova-Krstevski, Vesna, Rohde, Paul R., Ng, Chai-Ann, Sachs, Frederick, Gottlieb, Philip A., Martinac, Boris
Pubblicato in Nat Commun (2016)

Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations

di Perry, Matthew D., Ng, Chai Ann, Phan, Kevin, David, Erikka, Steer, Kieran, Hunter, Mark J., Mann, Stefan A., Imtiaz, Mohammad, Hill, Adam P., Ke, Ying, Vandenberg, Jamie I.
Pubblicato in J Physiol (2016)

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel K(V)11.1

di Kozek, Krystian A., Glazer, Andrew M., Ng, Chai-Ann, Blackwell, Daniel, Egly, Christian L., Vanags, Loren R., Blair, Marcia, Mitchell, Devyn, Matreyek, Kenneth A., Fowler, Douglas M., Knollmann, Bjorn C., Vandenberg, Jamie I., Roden, Dan M., Kroncke, Brett M.
Pubblicato in Heart Rhythm (2020)