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Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

Proteins that form ion-selective pores in the membrane of cells are integral to many rapid signaling processes, including regulating the rhythm of the heartbeat. In potassium channels, the selectivity filter is critical for both endowing an exquisite selectivity for potassium ions, as well as for co...

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Autors principals: Perry, Matthew D., Ng, Chai Ann, Vandenberg, Jamie I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630859/
https://ncbi.nlm.nih.gov/pubmed/23471968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461442
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