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The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
The cytoplasmic N–terminal domain of the human ether–a–go–go related gene (hERG) K(+) channel is critical for the slow deactivation kinetics of the channel. However, the mechanism(s) by which the N–terminal domain regulates deactivation remains to be determined. Here we show that the solution NMR st...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3020963/ https://ncbi.nlm.nih.gov/pubmed/21249148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016191 |
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