The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

The cytoplasmic N–terminal domain of the human ether–a–go–go related gene (hERG) K(+) channel is critical for the slow deactivation kinetics of the channel. However, the mechanism(s) by which the N–terminal domain regulates deactivation remains to be determined. Here we show that the solution NMR st...

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Main Authors: Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela, Vandenberg, Jamie I.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020963/
https://ncbi.nlm.nih.gov/pubmed/21249148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016191
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