A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor negative and positive breast cancers

BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous recombination (HR) DNA repair, cell-cycle checkpoints, and transcriptional regulation. BRCA1 germline mutations confer a high risk of early-onset breast and ovarian cancer. In >80% of cases, tumours arising in BRCA1...

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書誌詳細
出版年:J Pathol
主要な著者: Natrajan, Rachael, Mackay, Alan, Lambros, Maryou B, Weigelt, Britta, Wilkerson, Paul M, Manie, Elodie, Grigoriadis, Anita, A’Hern, Roger, van der Groep, Petra, Kozarewa, Iwanka, Popova, Tatiana, Mariani, Odette, Turaljic, Samra, Furney, Simon J, Marais, Richard, Rodruigues, Daniel-Nava, Flora, Adriana C, Wai, Patty, Pawar, Vidya, McDade, Simon, Carroll, Jason, Stoppa-Lyonnet, Dominique, Green, Andrew R, Ellis, Ian O, Swanton, Charles, van Diest, Paul, Delattre, Olivier, Lord, Christopher J, Foulkes, William D, Vincent-Salomon, Anne, Ashworth, Alan, Stern, Marc Henri, Reis-Filho, Jorge S
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976800/
https://ncbi.nlm.nih.gov/pubmed/22362584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4003
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