Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines

BACKGROUND: Gene fusions arising from chromosomal translocations have been implicated in cancer. However, the role of gene fusions in BRCA1-related breast cancers is not well understood. Mutations in BRCA1 are associated with an increased risk for breast cancer (up to 80% lifetime risk) and ovarian...

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Main Authors: Ha, Kevin CH, Lalonde, Emilie, Li, Lili, Cavallone, Luca, Natrajan, Rachael, Lambros, Maryou B, Mitsopoulos, Costas, Hakas, Jarle, Kozarewa, Iwanka, Fenwick, Kerry, Lord, Chris J, Ashworth, Alan, Vincent-Salomon, Anne, Basik, Mark, Reis-Filho, Jorge S, Majewski, Jacek, Foulkes, William D
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227591/
https://ncbi.nlm.nih.gov/pubmed/22032724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-75
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