Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

Therapies that target estrogen signaling have made a very considerable contribution to reducing mortality from breast cancer. However, resistance to tamoxifen remains a major clinical problem. Here we have used a genome-wide functional profiling approach to identify multiple genes that confer resist...

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Detalhes bibliográficos
Main Authors: Mendes-Pereira, Ana M., Sims, David, Dexter, Tim, Fenwick, Kerry, Assiotis, Ioannis, Kozarewa, Iwanka, Mitsopoulos, Costas, Hakas, Jarle, Zvelebil, Marketa, Lord, Christopher J., Ashworth, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Breast Cancer Special Feature
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286962/
https://ncbi.nlm.nih.gov/pubmed/21482774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018872108
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