Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to α-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1) the inactive intermediate, prethrombin; or (2) t...

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Veröffentlicht in:Blood
Hauptverfasser: Shaw, Maureen A., Kombrinck, Keith W., McElhinney, Kathryn E., Sweet, David R., Flick, Matthew J., Palumbo, Joseph S., Cheng, Mei, Esmon, Naomi L., Esmon, Charles T., Brill, Alexander, Wagner, Denisa D., Degen, Jay L., Mullins, Eric S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974202/
https://ncbi.nlm.nih.gov/pubmed/27252233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-680280
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