Tumor cell–associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell–dependent and–independent mechanisms

Tumor cell–associated tissue factor (TF) is a powerful determinant of metastatic potential. TF may increase metastasis by supporting thrombin-mediated proteolysis, through intracellular signaling events mediated by the TF cytoplasmic domain, through TF/fVIIa/fXa–mediated activation of protease-activ...

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Detalhes bibliográficos
Main Authors: Palumbo, Joseph S., Talmage, Kathryn E., Massari, Jessica V., La Jeunesse, Christine M., Flick, Matthew J., Kombrinck, Keith W., Hu, Zhiwei, Barney, Kelley A., Degen, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896107/
https://ncbi.nlm.nih.gov/pubmed/17371949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-065995
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