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Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency

Whole genome sequencing of an individual completely devoid of plasma- and platelet-derived factor V (FV) identified 167 variants in his F5 gene including previously identified and damaging missense mutations at rs6027 and Leu90Ser. Because the administration of fresh frozen plasma (FFP) prevents gas...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bouchard, Beth A., Chapin, John, Brummel-Ziedins, Kathleen E., Durda, Peter, Key, Nigel S., Tracy, Paula B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458802/
https://ncbi.nlm.nih.gov/pubmed/25896652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-589580
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