Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to α-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1) the inactive intermediate, prethrombin; or (2) t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Shaw, Maureen A., Kombrinck, Keith W., McElhinney, Kathryn E., Sweet, David R., Flick, Matthew J., Palumbo, Joseph S., Cheng, Mei, Esmon, Naomi L., Esmon, Charles T., Brill, Alexander, Wagner, Denisa D., Degen, Jay L., Mullins, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974202/
https://ncbi.nlm.nih.gov/pubmed/27252233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-680280
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados