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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice
Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to α-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1) the inactive intermediate, prethrombin; or (2) t...
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| Publicat a: | Blood |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4974202/ https://ncbi.nlm.nih.gov/pubmed/27252233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-680280 |
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