The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A

Thrombin is a positive mediator of thrombus formation through the proteolytic activation of protease-activated receptors (PARs), fibrinogen, factor XI (fXI), and other substrates, and a negative regulator through activation of protein C, a natural anticoagulant with anti-inflammatory/cytoprotective...

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Detalhes bibliográficos
Main Authors: Flick, Matthew J., Chauhan, Anil K., Frederick, Malinda, Talmage, Kathryn E., Kombrinck, Keith W., Miller, Whitney, Mullins, Eric S., Palumbo, Joseph S., Zheng, Xunzhen, Esmon, Naomi L., Esmon, Charles T., Thornton, Sherry, Becker, Ann, Pelc, Leslie A., Di Cera, Enrico, Wagner, Denisa D., Degen, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122951/
https://ncbi.nlm.nih.gov/pubmed/21436072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-304915
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