Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin

A pre-existing, allosteric equilibrium between closed (E*) and open (E) conformations of the active site influences the level of activity in the trypsin fold and defines ligand binding according to the mechanism of conformational selection. Using the clotting protease thrombin as a model system, we...

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Vydáno v:Sci Rep
Hlavní autoři: Pelc, Leslie A., Koester, Sarah K., Chen, Zhiwei, Gistover, Noah E., Di Cera, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707225/
https://ncbi.nlm.nih.gov/pubmed/31444378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48839-1
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