Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of...

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Publicado en:Blood
Autores principales: Hope, Chelsea, Foulcer, Simon, Jagodinsky, Justin, Chen, Sarah X., Jensen, Jeffrey L., Patel, Sanjay, Leith, Catherine, Maroulakou, Ioanna, Callander, Natalie, Miyamoto, Shigeki, Hematti, Peiman, Apte, Suneel S., Asimakopoulos, Fotis
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974200/
https://ncbi.nlm.nih.gov/pubmed/27259980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705780
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