Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Hope, Chelsea, Foulcer, Simon, Jagodinsky, Justin, Chen, Sarah X., Jensen, Jeffrey L., Patel, Sanjay, Leith, Catherine, Maroulakou, Ioanna, Callander, Natalie, Miyamoto, Shigeki, Hematti, Peiman, Apte, Suneel S., Asimakopoulos, Fotis
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2016
Aiheet:
Lymphoid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974200/
https://ncbi.nlm.nih.gov/pubmed/27259980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705780
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