Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Hope, Chelsea, Foulcer, Simon, Jagodinsky, Justin, Chen, Sarah X., Jensen, Jeffrey L., Patel, Sanjay, Leith, Catherine, Maroulakou, Ioanna, Callander, Natalie, Miyamoto, Shigeki, Hematti, Peiman, Apte, Suneel S., Asimakopoulos, Fotis
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2016
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974200/
https://ncbi.nlm.nih.gov/pubmed/27259980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705780
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