TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma–associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interle...

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Autors principals: Hope, Chelsea, Ollar, Samuel J., Heninger, Erika, Hebron, Ellen, Jensen, Jeffrey L., Kim, Jaehyup, Maroulakou, Ioanna, Miyamoto, Shigeki, Leith, Catherine, Yang, David T., Callander, Natalie, Hematti, Peiman, Chesi, Marta, Bergsagel, P. Leif, Asimakopoulos, Fotis
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046426/
https://ncbi.nlm.nih.gov/pubmed/24723682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554071
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